In a few months, my son will get the MMR vaccine. I count myself very fortunate to live in a place and time when this amazing protection against is made available for free, and I will of course have him vaccinated. When I had my oldest child vaccinated, nearly 10 years ago, there was (at least where I lived, Belgium) no vaccine debate. I was dimly aware there were some very religious people who refused vaccines, but they were so clearly an outgroup that people did not seriously consider them and their arguments. Not vaccinating didn't even seem like a live option to me. Now, fast-forward post-Wakefield UK…


Vaccines are no longer the obvious, uncontroversial medical procedure they once were. "Are you planning to have your baby vaccinated" (ask healthcare visitors) And if I say yes,  I hear what a wise decision it is, and that I need not worry about autism. In fact, NHS leaflets, baby books and other materials invariably tell me (rightly) that the link between vaccines and autism has been debunked. Yet I caught myself thinking "Is it really safe?" This thought was followed by "Of course it is, why am I even thinking this!" Thanks to my scientific training and background in philosophy of science, and my access to journals behind paywalls, I am able to read and interpret the retraction of the original research. But many parents are not in my position and have to rely on various lines of testimony. By trying to assuage fear brought about by anti-vaxxer campaigns, these materials are in effect playing into them, by acknowledging there's still a controversy (the UK numbers are recovering from the decline brought about by Wakefield's research, so hopefully this trend continues). 

It is a well-known phenomenon that it's impossible not to think of a polar bear who's driving a red car, when I've just put that thought into your mind as you are reading it. Similarly, all the leaflets that try to debunk the autism-vaccine link vividly put in parents' minds that vaccines might somehow cause autism. Recent research shows this is no fringe concern: a recent survey found that only 37% of parents disagree with the statement that vaccines cause autism. Even 39% of parents who are pro-vaccine say they are unsure. The reason is precisely because vaccines and autism have been linked in the public eye, and anti-anti-vaccine campaigns that want to debunk this are in effect strengthening the association.

But fears about autism, no matter how irrational and ungrounded, cannot entirely explain why some parents are so dead set against vaccines. One recent study by Brendan Nyhan et al. in Pediatrics found that debunking the vaccine-autism link does help to decrease the perceived risk, but this does not change anti-vaccine parents. In fact, surprisingly, finding out they were mistaken in believing this link made the parents even more, not less, likely to reject vaccines. This is a deeply troubling finding. Even more troubling, none of the campaigns they tested seemed to sway anti-vaccine parents' opinions. The Slate commentary states that this is simply due to the fact that "people become more assured of their stupid opinions when confronted with factual or scientific evidence proving them wrong." Even if that is true, there used to be a lot of sentiments against vaccines before (when they were first introduced), as there were against other medical inventions. So we need to focus again, I think, on pro-vaccine campaigns instead of anti-anti-vaccine campaigns. The primary message shouldn't be "Here's why anti-vaccine campaigners are wrong", but "Here's why you should have your children vaccinated". 

One of the great modern campaigners for vaccines was Lady Mary Wortley Montagu, who introduced inoculation against smallpox in England nearly 80 years before Jenner. Her introduction of a Turkish technique of inoculation made Jenner's later experiments and his development of vaccination (a safer procedure, as it used cowpox) possible. She learned about inoculation by seeing it performed by Greek women in Turkey, where she was living with her husband (who was an ambassador). Upon her return to England, she enthusiastically promoted the procedure, but there was a lot of initial distrust of the method, as it came from the east and thus was thought prima facie unreliable. Lady Mary Wortley offered both her son and daughter as subjects to prove the reliability of the method. To further convince skeptics, she anonymously published "A Plain Account of the Inoculating of the Small Pox by a Turkey Merchant" in a London newspaper (I have been unable to find a copy online, unfortunately).

Lady Montagu was able to successfully promote inoculation as a proven technique to prevent smallpox, a remarkable feat given the initial distrust of the procedure, and the 3% mortality rate of her technique, which was vastly better than catching the disease (up to 40% mortality rate, but still a great deal less safe than today). We can learn from her story and others on how to develop on a positive message of pro-vaccine, rather than anti-anti-vaccine. Debunking is fine, and but it needs to be accompanied with a cultural sensitivity (as Kahan puts it) for the doubting parents, treating them not as idiots but as people whose concerns and fears are taken seriously.

Kahan argues (and has empirical support) for his claim that the medium in which the message is brought is of vital importance to convince a doubting public of the reality of things like climate change. Debunking by itself, or websites with death counts, are unlikely to sway skeptics and may even lead to an undesirable polarization of attitudes. From a consequentialist perspective, our primary focus should not be to prove the anti-vaccine promoters wrong but to make sure to create a climate where parents again accept vaccination as the obvious, safe choice for their children. As Lady Montagu wrote " 'Tis no way my interest (according to the common acceptation of that word) to convince the world of their errors; that is, I shall get nothing by it but the private satisfaction of having done good to mankind, and I know no body that reckons that satisfaction any part of their interest."

 

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15 responses to “How to promote the safety and effectiveness of vaccines”

  1. Sara L. Uckelman Avatar

    There was an opinion piece that went around Facebook a month or so back that I found particularly compelling: Pediatrician: Vaccinate Your Kids—Or Get Out of My Office. In particular, the sub-title really resonated with me: “If you won’t trust your doctors on vaccinating your kids, will you ever really trust them at all?”
    I was very pleased that we moved from the Netherlands to Germany right about the time my daughter would have gotten her first chicken pox vaccination. They don’t routinely vaccinate against that in the Netherlands, and I share the same sentiment as her German pediatrician: That’s just stupid.

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  2. dmf Avatar

    not sure what weight “will you ever really trust them at all” is going to carry with people/patients as we don’t(and can’t)live/choose along the lines of such absolutes/imperatives. The question of whether the treatment ‘contracts’ between clinicians and consumers should go both ways and not just bind the clinicians to the choices of patients is a vital one and perhaps where the real power for change (reworking the current struggles over failures of patient “compliance”)in such matters will come from.

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  3. Unsure Avatar
    Unsure

    I was once ardently pro-vaccine, but I’ve become less sure. The question should be, I think, whether the chance that the vaccine is going to hurt my child is greater than the chance of my child catching the disease. For example, Pandemrix, an H1N1 vaccine, leads to a 7x greater risk of narcolepsy. http://sciencenordic.com/study-explains-why-h1n1-flu-can-cause-narcolepsy So, should I get (or give my kid) the H1N1 vaccine? I’m not sure the answer is obvious.
    I think people who know more about this than I do should, in addition to pointing out that vaccines don’t cause autism, argue that even though they are known to cause some problems, they’re still better than the alternative. In an attempt to try to convince the crazies who don’t vaccinate at all to do so, there are a lot of reasonable people still wondering what to do. There your Lady Montague story (3% chance of death if vaccinated v 40% if caught) seems on the right track.

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  4. Mark Navin Avatar

    Thanks for this, Helen.
    I agree that “trying to assuage fear brought about by anti-vaxxer campaigns” may end up making things worse. Kahan has argued (with evidence) that merely learning that some people do not vaccinate makes parents less likely to vaccinate their children. So, the problem is not only that core vaccine refusers will not change their minds (as the Nyhan et al study shows), but that the mere existence of vaccine refusal makes parents who would otherwise vaccinate their children more hesitant about vaccination.
    I also agree that public health officials (and academics, citizens and others who care about public health) would do well to support ‘pro-vaccine’ campaigns rather than merely resist ‘anti-vaccine’ forces. I worry, though, that pro-vaccine campaigns face some struggles that late-19th and early-20th century pro-vaccine campaigns might not have faced (of course I’m not an historian).
    First, the benefits of vaccination were large and epistemically accessible. Smallpox killed a lot of people and everyone knew someone who had suffered from that disease. Many of today’s vaccines protect against diseases that are less harmful than smallpox (e.g. chicken pox) or that most people do not have direct experience of (e.g. measles).
    Second, much of force behind the early vaccine movements was a religious objection to vaccination (i.e. as ungodly contamination), rather than a rejection of the expertise of medical authorities. But today’s vaccine refusal more often takes the shape of organized resistance to the expertise of pediatricians (and immunologists, etc.). (Sara points us towards a nice example.) While earlier anti-vaccine folks were self-consciously ‘anti-science’, today’s are more likely to be ‘pro-science’, but epistemically self-reliant. (As a consequence, they are especially vulnerable to various cognitive biases that reinforce their refusal of vaccines.) And while there is some low-hanging fruit (e.g. promoting greater time for conversation between parents and pediatricians), it is not clear what could be done to significantly (re)build parental trust in the medical establishment among these parents. (But, of course, such parents may not be the target audience of pro-vaccine movements.)
    Third, earlier pro-vaccine movements benefited from broader social and political movements aimed at cultivating forms of ‘voluntary’ participation in public projects. I think, for example, of the cultivation of patriotism in support of military conscription in WWI (and the ways that vaccine movements got linked to that effort). For a later example, consider that the US polio trials in the 1950s experimented on the bodies of over a million public school children – with the willing involvement of parents, schools, local political officials, etc. But those days are gone. In my state of Michigan we cannot even get the legislature to agree to fix public roads and bridges – even as they crumble around us.

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  5. Helen De Cruz Avatar

    Hi unsure: I agree that it’s not an all-or-nothing case for vaccines, and that their merits should be assessed separately (for instance, influenza vaccines like you mention may not be as advisable as vaccines against polio, measles etc). I’m no expert on vaccines, so I cannot say.
    Mark Navin points out the problem of epistemic inaccessibility. Thanks to herd immunity, the bad effects of vaccines aren’t accessible to us as they were even 50, 60 years ago. My mother as a child had a very serious bout of diphtheria, and if I look further down the family tree, there are great-uncles etc who died of preventable children’s diseases. The way people try to make this vivid now is by showing vivid pictures of people who have measles, mumps etc, but the Paediatrics article indicates that this did not sway parents to vaccinate their children. Also a story of a 10-month-old who got very ill from the measles because he caught the disease from an unvaccinated older child did not seem to help (in fact, none of the stories helped). So we have a problem of epistemic opacity here: knowing people around you who have died from these diseases (as Lady Montagu did, she lost a brother, and nearly died of smallpox as an adult) is clearly more of a motivator than gruesome pictures of unknown people or stories of unknown children. I think it’s important to keep the historic dimension in mind, and to emphasize how much progress has been made in eradicating these diseases. I’m not sure in how far such campaigns would help (I know they exist, but they weren’t specifically tested in the article I discuss in the main post).

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  6. Helen De Cruz Avatar

    Hi Mark: thanks for these very relevant observations! I am also wondering about the role of belief in progress and building societal change together, and how this has changed over the past decades.
    Voluntary participation in public projects took place in a climate where people had more trust than today in the government’s efficacy in making things happen. If we look at what was achieved (until the 50s and 60s) in terms of infrastructure, the availability of higher education etc, it is hard to imagine things of this scale happening today (in fact, the reverse happens, for instance with the privatization of the railroads here, or the upcoming privatization of the Royal Mail). In a climate like this, skepticism against government-directed efforts is perfectly understandable. As you say, if governmental agencies can’t even fix potholes in roads, why would it seem plausible to people that they help our kids stay healthy? This surely helps foster a skeptical climate where conspiracy theories about governments being in the pockets of big pharma run rampant (as the survey I linked to also indicates).

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  7. Concerned Parent Avatar
    Concerned Parent

    Did you ever read the vaccine insert? This article is total nonsense, to talk other parents into your beliefs that could damage them permanently shame shame. https://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf

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  8. Mark Lance Avatar
    Mark Lance

    Yeah, concerned parent: I’ve read them. All of them. Parents should not even have this choice. The bulk of childhood vaccinations are so crucial for the health of your children, other children, immune-suppressed adults, etc. that allowing you to “choose” is like allowing the alcoholic to choose whether to drive drunk. The shame here falls on the anti-scientific fear-mongering crowd.
    Unsure: You do know that H1N1 kills people, right? Lots of them. (Again, not just the person who fails to get vaccinated, but everyone they infect.) And that’s quite a lot worse than a tiny risk of falling asleep.

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  9. GiT Avatar
    GiT

    7×0=0.
    Not that the base rate in question here is 0. But 7x more likely by itself is just meaningless fear mongering.

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  10. Concerned Parent Avatar
    Concerned Parent

    Parents should not even have WHAT choice? To know what they are putting in their bodies or the choice to not be Force Medicated and that is a dangerous position and reckless. You have put all your faith in big MERK and no faith in your body, nutrition, or the genetic code that you pass on to your children. Let me guess, you are a supporter of the nazis because thats exactly how they did what they did, forced medication and hospitalization. Who poses a threat, if your vaccinated then non-vaccinated people should pose no risk to you. And then you will turn around and say we could stop vaccinating if every one was vaccinated, people who are not vaccinated are the risk, well then where did the disease start before there was a vaccine? Many of the diseases we vaccinate against have not surfaced in any meaningful way for many many years but we keep vaccinating for them, why. One of the risks of vaccination is contracting the disease from the vaccine, so the people who keep vaccinating for diseases that are no longer a threat may be the cause of outbreaks in the first place. Are you all saying the human race cannot survive without mass regular vaccination. sounds like the anti scientific community is right here in this blog, look at you all saying that only one scientific opinion is correct and the others are not, you are the ones making it so we cannot move past vaccines and replace them with real health. What a waste of my time to even read this article

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  11. Mark Navin Avatar

    Hi, Helen: We might also point to the way that the state provides parents, in particular, with inadequate support. The absence of adequate public support for parents, including subsidized daycare and other provision for children with vaccine complications, along with a culture that is hypercritical of parents’ (and especially mothers’) choices, may make parental hyper-vigilance more reasonable than it otherwise would be.
    Of course, vaccine refusal may still be immoral and it may be (as Mark Lance says) that the state is permitted to (or should) coerce vaccination. (I agree with both of these claims.) But, then it matters all the more that the state has contributed to the fact that parents refuse to grant appropriate credibility to the testimony of pediatricians (and other medical authorities).

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  12. Mark Navin Avatar

    Hi, Concerned Parent: I want to respond to a couple of things you say that I think are mistaken.
    First, your concern about being “Force Medicated” and your guess that Mark Lance supports Nazi medical experiments is not apt (to put it mildly). The bioethical ideal of patient autonomy is not central to discussions about the voluntariness of vaccination, since vaccination is not primarily a form of private medical treatment. This is for three reasons:
    One, the state may constrain the choices of children (and the choices that parents make for children) for paternalistic reasons, at least when there is significant risk of serious harm in the absence of state intervention. And unvaccinated children are much more likely to suffer from childhood diseases, and to experience lifelong disabilities from these diseases than are vaccinated children.
    Two, the state has the authority to coerce people to take reasonable means to significantly reduce the risk of causing serious harm to others, and becoming vaccinated is a reasonable means by which to significantly reduce the risk of causing serious harm to others. This is because unvaccinated children are much more likely to infect other people than are vaccinated children.
    Three, societies have the authority to restrict individuals’ liberty in order to assure that everyone pays their fair share for public goods, and vaccination is a means by which (most) persons can make a fair contribution to herd immunity (and, thereby, to the goods that herd immunity provides).
    Second, you say: “Who poses a threat, if your vaccinated then non-vaccinated people should pose no risk to you.”
    This is false. One, vaccination does not always generate individual immunity. So, yes, unvaccinated people may harm me even if I am vaccinated. Two, some people cannot become vaccinated (because they are too young or immunocompromised). You place these people at risk by not vaccinating. Again, vaccination choices are not fundamentally choices about personal medical treatment.
    I don’t pretend that I will convince you. (We should be doubtful of this, given the studies Helen links to.) But I want to make sure that your views are not left unchallenged.

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  13. Concerned parent Avatar
    Concerned parent

    Vaccination is actually a cause of a suppressed immune system my friend:
    Immune Suppression By Live Virus Containing Vaccines Dr. Blaylock
    It is also known that certain viruses powerfully suppress immunity, such as the measles virus.35 The MMR vaccine contains live measles viruses and recent studies have shown that immune suppression after vaccination with this virus suppresses immunity in a profound way that last as long as six months.36-41 In fact, the CDC recommends separating this vaccine from other live virus vaccines to prevent viral overgrowth (Yet, they combine it with two other live viruses-rubella and mumps viruses).
    Yet, they never address the obvious question –wouldn’t this vaccine also make the child more susceptible to other naturally occurring infections such as hemophilus B influenza meningitis, meningococcal meningitis, persistent measles infection, influenza infection and even chickenpox? This has been strongly suggested by a number of studies.42 Not only would they be more susceptible, but severe complications and even death would be more common as well.
    When death and severe complications occur due to these infections, pediatricians, the CDC and the American Academy of Pediatrics use this as a justification for more vaccines, never admitting that the increase incidence of these infections and complications was caused by their previous vaccine recommendations.
    This risk is especially high in families with a number of other children in the household or in children in day care centers. With a prolonged suppressed immune system, exposure to other sick children would put this child at a high risk of contracting the infection and of having complications or dying from the infection as stated.
    Studies have also shown that vaccines that cover only a few strains of a virus or bacteria that naturally have a great number of strains (some have over a hundred strains), can cause a shift in strain dominance so that the strain not included in the vaccine then becomes the dominant disease causing strain. We see this with the meningiococcal and pneumococcal vaccines.43-45 This is discussed in the scientific literature but the public is never informed. Most pediatricians are completely unaware of this.
    When combined with mercury, which is also an immune suppressing substance, the effect is compounded. Fluoroaluminum, formed in fluoridated drinking water, also interferes with immune function, as do many insecticides and herbicides used around the home.46
    Often forgotten, is the substantial evidence that omega-6 oils powerfully induce inflammation and immune suppression when consumed in large amounts. Those eating a Western diet are consuming 50-fold higher amounts of this type of oil (called linoleic acid) than needed for health. These oils include corn, safflower, sunflower, canola, peanut and soybean oils. So, we see that the average child is exposed to a number of substances in their food and environment that can also alter immunity, making them not only more susceptible to natural infection, but also to vaccine complications.
    In essence, by overvaccinating our children, public health officials are weakening their immune system, making them more susceptible to a number of infections and less able to combat the infections. This gives them an endless source of “horror stories” to justify even more vaccines. Remember also that mercury is an immune suppressant, that both from vaccines and seafood contamination.
    One can see that a pregnant mother having dental amalgam fillings who eats a diet high in methylmercury-containing seafood and living in an area with high atmospheric mercury, such as West Texas, would be at a greater risk of having an autistic child than one not exposed to these other sources of mercury. These differences in environmental mercury exposure are never considered by those insisting all children have the same vaccines, including mercury-containing vaccines such as the flu vaccine.

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  14. Helen De Cruz Avatar

    Concerned parent: Just to be clear – I understand that a lot of the “studies” you cite are in circulation in anti-vaccine circles. The levels of mercury are in fact very low and in the UK they don’t even use mercury in the MMR vaccine (http://www.nhs.uk/Conditions/vaccinations/Pages/mmr-questions-answers.aspx#thiomersal)
    But I do not wish to debate the safety of vaccines here. I take it as evident that vaccines have tremendous health benefits that you (and I) are unable to assess directly because of the herd immunity against severe child diseases that now exists.
    I do not wish to debate this, because, as the study I cite above shows, it is pointless to debate it – debate usually just has a polarizing effect: as the cognitive science literature shows, it will just lead people to be more entrenched in their views. If you feel like debating the safety of vaccines, you are welcome to do so in a forum of your own choosing, where you can read things that accord with what you already believe.
    I am also a concerned parent. In fact, what prompted me to write this article was that my son was ill and had many small spots on his body. I phoned the doctor, who asked me to come and see her immediately, because she wanted to make sure it wasn’t measles and rubella. The fact that a medical doctor thought my son (who is too young for the MMR vaccine) would be at risk of measles was very alarming (fortunately, it wasn’t measles). Before the whole autism scare, this would never have been an issue.
    I wrote the blogpost in the supposition that vaccines are a tremendous health benefit, and that anti-vaccine campaigns pose a great health risk. So I am interested in thinking about policies that would increase the uptake of vaccine, and decrease the bad effects of scaremongering.
    This being said, I hope you understand that I will not directly debate the risks and benefits of vaccines. It is pointless and polarizing, and does not fall within the purview of this blogpost’s aims. I realize why parents feel concerned, and I do not think parents who are concerned or who believe the anti-vaccine propaganda are irrational (see also discussion above, the lack of support for parents in other domains). But ultimately, the aim should be to get vaccination rates very high so that all children (including those who are unable to get vaccines, or whose parents remain unmoved) are safe from childhood diseases.

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  15. Concerned Parent Avatar
    Concerned Parent

    There is no difference between you and I, you are using what you see as valid science and so am I. You are using ‘scaremongering’ to get people to do what YOU think is right and so am I. What concerns me is that you have no interest in making the vaccines safer or implementing policies that make sure doctors are better informed of both sides of the story.
    “So I am interested in thinking about policies that would increase the uptake of vaccine, and decrease the bad effects of scaremongering.”
    You have only an interest in making sure people get vaccinated without questioning it is how I see it and who knows i may be wrong.
    But by you saying that the autisim/brain damange has been debunked or that parents who point out high health risks or identify negative side effects from vaccination you are also suppressing valid research into ways that people can be safe from disease through nutrition, whole medicine etc who CANNOT GET VACCINATED. You see, you have polarized the conversation within the first 5 paragraphs of your blog.
    If you really care you will promote a healthy body first because that is where all of this starts, a healthy body. You can inject as many vaccines as you like, that is YOUR choice, but it fixes nothing when the body is already sick. There are many people who cannot be vaccinated for many reasons so why don’t you help the debate by at least publishing the benefits of our powerful bodies being nourished with the needed compounds to fight all infections? This is where your entire cause will fail because we parents see through your type of scaremongering because we are informed as well. The entire ‘anti-vaccine’ movement is all about a healthier body and moving past vaccinating for every disease we can make a vaccine for. Your movement is the element suppressing advanced health research. But i guess in the next few years we will move to forcing parents to have 90 + vaccines for their kids and yes this is the direction of the immunize by 2 program, just watch, welcome to our future, vaccinated from birth until death sounds lovely.

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